Cannabidiol (CBD) is highly prized for its anxiolytic properties. According to mounting evidence, this cannabis derivative can relieve stress and anxiety nearly as effectively as conventional antidepressants.
Besides, pure CBD is non-psychoactive. The compound will calm your nerves without inducing the infamous “couch-lock” associated with its psychedelic cousin - tetrahydrocannabinol (THC).
CBD is also safer than most synthetic antidepressant medications. Adverse events are extremely rare, provided that you observe the recommended dosage guidelines.
And even if unpleasant effects occur, they’re usually mild and short-lived.
But before administering CBD, it’s best to understand how this cannabinoid works.
We’ve prepared a comprehensive guide to cannabidiol’s mellowing effects, with a focus on CBD flower. Read below for insights into how to effectively use CBD flower for anxiety.
What Is CBD Flower?
CBD flower denotes raw, unprocessed cannabis buds. The term specifically refers to flowers harvested from cannabis strains meticulously bred to be higher in CBD than THC.
Note that marijuana cultivars inherently differ in their cannabinoid profile.
CBD-high strains are famous for their relaxing benefits. Besides, these cultivars deliver broad-spectrum therapeutic benefits without inducing severe mind-altering effects.
On the flipside, THC-high strains generally appeal to recreational cannabis users. The dense THC concentration in these cultivars can trigger euphoria, which typically presents as happiness, increased motivation, and elevated alertness.
Perhaps we should also underscore that THC and CBD aren’t the sole cannabinoids in cannabis. The plant produces at least 100 other cannabinoids, including lesser-known ones like tetrahydrocannabinolic acid (THCA).
THCA is an inert acid that exists as a precursor to THC. Despite their near-similar molecular formula, THCA and THC differ fundamentally in their mind-altering effects.
Tetrahydrocannabinolic acid is non-psychoactive. The compound acquires psychedelic properties when it converts to tetrahydrocannabinol via a heat-dependent process known as decarboxylation.
Decarboxylation strips THCA’s molecule of one carboxyl group, resulting in the potent mind-altering THC.
Other minor cannabinoids in CBD flower include cannabinol (CBN), cannabigerol (CBG), and cannabichromene (CBC). All of these compounds contain some anxiolytic properties and can compound CBD’s antidepressant properties.

How Does CBD Work?
Like other phytocannabinoids (plant-derived cannabinoids), CBD exerts its biological effects through the endocannabinoid system (ECS). The endocannabinoid system is a complex cell modulatory network in all vertebrates, responsible for regulating various physiological processes.
The ECS plays a critical role in immune function. It’s also involved in mood regulation, pain management, appetite control, and the signaling of hormones like cortisol.
To function effectively, the endocannabinoid system relies on a network of receptors called endocannabinoid receptors. These receptors interact with the body’s internal cannabis-like molecules called endocannabinoids.
Besides, the endocannabinoid system relies on certain enzymes and hormones.
The cannabidiol in CBD flower interacts with the endocannabinoid system through CB2 receptors.
CB2 receptors are endocannabinoid receptors spread throughout the peripheral organs and tissues. They differ from their CB1 counterparts, which are mostly expressed in the central nervous system (CNS).
CBD may also increase endocannabinoid levels. That’s due to its ability to block the enzymes that degrade these naturally occurring lipid molecules.
How Might CBD Flower Ease Anxiety?
1. Inhibiting Cortisol Levels
Cortisol is the primary stress hormone. It notably regulates the “fight-or-flight” responses, making it invaluable during moments of critical decision-making.
However, excess cortisol levels can lead to chronic stress and restlessness. The hormone may also diminish the function of other important neurotransmitters, impacting your immunity.
Smoking CBD flower may help regulate cortisol’s production and signaling.
According to a randomized clinical trial, researchers observed that cannabidiol could reduce cortisol levels significantly in the study subjects. More interesting is that CBD exerted its inhibitory effects on cortisol without impacting other neurotransmitters.
2. Boosting Serotonin Signaling
Serotonin is one of the principal neurotransmitters that induce natural “feel-good” vibes. While the hormone usually works synergistically with dopamine, it’s just as effective on its own.
Consuming CBD flower may increase serotonin signaling, improving relaxation.
Previous studies have shown that CBD boosts serotonin by interacting with two key serotonin receptors - the 5-HT3A and 5-HT1A.
As a serotonin agonist, CBD flower can potentially replace selective serotonin reuptake inhibitors (SSRIs). SSRIs are a class of conventional antidepressants that work by activating serotonin signaling.
3. Increasing Anandamide Levels
Anandamide is a popular endocannabinoid that plays a critical role in stress mediation. Stressful experiences can deplete the brain’s anandamide levels. Low anandamide exacerbates existing anxiety, creating a vicious cycle.
Fortunately, you can enjoy natural anxiety relief with CBD flower. Cannabidiol boosts anandamide levels by inhibiting fatty acid amide hydrolase (FAAH).
FAAH is notorious for breaking down various endocannabinoids, including anandamide. CBD doesn’t desensitize FAAH directly. Rather, it competes for this enzyme with anandamide, minimizing the latter’s degradation.
4. Modulating THC Levels
All unprocessed CBD flowers contain some tetrahydrocannabinol. Due to THC’s uplifting effects, smoking flowers with moderate amounts of this substance might provide compounded relief from anxiety.
However, THC may also spike cortisol levels. That makes it challenging to predict the substance’s anxiolytic properties. The good news is that CBD modulates THC’s effects.
Therefore, you can safely administer CBD flower with considerable THC levels without developing jitteriness caused by increased cortisol production.

How to Use CBD Flower for Anxiety
1. Consult a Doctor
Consult a licensed medical marijuana doctor before integrating CBD flower into your wellness routine. Candidly discuss your anxiety condition, reason for turning to CBD, and overall expectations.
Besides, disclose if you’re already on some prescription medications. Certain antidepressants and blood thinners can interact adversely with CBD, diminishing its efficacy.
2. Find a Supplier
Once a medical marijuana doctor prequalifies you for CBD use, proceed to find a reputable supplier.
Insist on a CBD store that has been in the industry for a reasonable length of time. It’s even better if the company enjoys convincing reviews from its previous customers.
Also, research how a store obtains its CBD flower.
To maximize the effects of CBD for stress relief, prioritize flowers sourced from organically cultivated hemp.
Be sure to also ascertain whether the buds undergo any additional curing.
At the least, ensure each flower undergoes two weeks of natural drying. This helps optimize its active cannabinoids and terpenes.
Most importantly, seek out laboratory-tested CBD flower. A certificate of analysis (CoA) should accompany each product.
The CoA is valid proof that a flower has undergone industry-mandated screening, a nod to its safety and purity. Remember to examine the analytical report for the product’s actual CBD and THC potency.
Professional marketing, responsive support, and competitive pricing are other considerations when looking for a reliable CBD flower store.
3. Choose a High-quality Flower
To examine the quality of CBD flower, analyze its color, texture, and taste.
Fresh CBD flowers will appear in vibrant shades of green. The buds may also appear yellow, depending on the strain.
Shun dull-colored flowers. A noticeable brownish tint points to a product that’s well past its sell-by date.
Next, ensure the trichomes are visibly thick, white or amber, and frosty. These properties indicate full maturity.
The best CBD flower should also be slightly sticky and spongy. However, it shouldn’t be excessively mushy or too crumbly.
As for the flavor profile, look out for a smooth and pleasant taste.
Note that you can only perform the flavor test after buying CBD flower. So, don’t skimp on the other requirements.
4. Mind Your Doses
To work out the best dosage for anxiety, determine your condition’s severity.
Higher serving portions would be effective for intense nervousness caused by stage fright, phobias, or panic attacks. Meanwhile, moderate doses will do for chronic anxiety disorders.
Many users often start with 10 - 20 milligrams (mg) of CBD/day, spread across 2 - 4 dosages.
But if you’re new to CBD flower, begin with smaller serving portions. Watch out for any unintended effects over 1 - 2 days before possibly increasing the serving portions.
5. Time Your Doses
Consume CBD flower late in the evening.
This will help you detox from the stressful experiences of the fading day, mellowing you down to peaceful sleep.
You can also smoke CBD for calm throughout the day to laze around.
Provided that you monitor your doses, the compound will quell racing thoughts while keeping you conscious of your surroundings.
When Do Effects Set In?
The effects of smoking CBD for calm largely depend on the doses consumed. As mentioned, higher serving portions will inevitably kick in sooner.
Your preferred cannabidiol formulation also determines how soon the substance will take effect.
When you compare CBD flower vs. oil for anxiety, you’ll realize that smoking delivers a faster onset time than taking oils or tinctures. That’s because the inhaled cannabinoid-rich smoke absorbs directly into your bloodstream through the mucous membranes in the lungs.
You can expect the effects within 5 - 20 minutes of taking the first puff. In contrast, sublingual administration takes 30 - 45 minutes to kick in.
The duration cannabinoids take in your system also depends on the active compounds in the smoked blend. While smoking delivers near-instant effects, the onset time is even shorter for CBD flowers containing significant THC levels.
THC readily impacts CB1 receptors located closer to the brain, explaining its faster onset time.

Wrap Up
Cannabidiol’s anxiolytic properties are well-documented. Studies have shown that CBD may help with different anxiety disorders if properly administered.
Whether you suffer from stage fright due to social anxiety disorder (SAD) or grapple with sleep deprivation induced by post-traumatic stress disorder (PTSD), a measured CBD dose can make a world of difference.
To make the most of cannabidiol’s anti-anxiety properties, insist on high-quality products.
Buy CBD obtained from organically-grown, laboratory-tested flowers. Then, administer the product in strict adherence to the recommended dosages.
Remember to also consult a licensed medical marijuana doctor before using CBD Flower for anxiety. This is particularly important if you’re already on a prescription for conventional antidepressants.
